Xia, Xi published the artcileSynthesis of diosgenyl quaternary ammonium derivatives and their antitumor activity, Computed Properties of 622-40-2, the publication is Steroids (2021), 108774, database is CAplus and MEDLINE.
Giosgenin is a naturally steroidal saponin exhibiting a variety of biol. activities including antitumor ones. A series of novel diosgenyl quaternary ammonium derivatives were designed and synthesized to develop potential anti-tumor agents in our research. All novel derivatives were characterized by 1H NMR, 13C NMR and HR-MS, and evaluated for their in vitro anti-proliferative activities using MTT assay. The human cancer cell lines were A549 (human lung cancer cell), H1975 (human lung adenocarcinoma cell), A431 (human skin squamous cell carcinoma), HCT-116 (human colorectal adenocarcinoma cell), Aspc-1 (human metastatic pancreatic cancer cell), Ramos (human B lymphoma cell), HBE (human bronchial epithelioid cell) and LO2 (human normal hepatocyte).
Steroids published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C8H13NO3, Computed Properties of 622-40-2.
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