Wang, Jingchen published the artcileOptimization of synthesis process for sodium ascorbate, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2012), 550-553(Pt. 1), 10-15, database is CAplus.
With 2-keto-L-gulonic acid(2KLG) and methanol as raw materials, 98% concentrated sulfuric acid as catalyst, the Me esterification reaction is occurred. Then with sodium carbonate as a transforming agent, through a conversion reaction sodium carbonate is obtained. In this experiment, the effects of reaction time, reaction temperature and reactant ratio on conversion rate of sodium ascorbate were studied. The results showed that sodium carbonate as the reactant of lactonization reaction can effectively shorten the reaction time and improve reaction yield. By experiment under the optimum process conditions: the reaction temperature is 65 °C, reaction time is 150 min and the molar ratio of 2-keto-L-gu Me to sodium carbonate is 1:0.6, the conversion rate reaches 98 % and the effect is better than with sodium bicarbonate as transforming agent.
Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C8H10N2O2, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.
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