Viger, Mathieu L. published the artcileDistinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast, Safety of 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Biomaterials (2017), 119-131, database is CAplus and MEDLINE.
Visualization of biochem. changes associated with disease is of great clin. significance, as it should allow earlier, more accurate diagnosis than structural imaging, facilitating timely clin. intervention. Herein, we report combining stimuli-responsive polymers and near-IR fluorescent dyes (emission max: 790 nm) to create robust activatable fluorescent nanoprobes capable of simultaneously detecting acidosis and oxidative stress associated with inflammatory microenvironments. The spectrally-resolved mechanism of fluorescence activation allows removal of unwanted background signal (up to 20-fold reduction) and isolation of a pure activated signal, which enables sensitive and unambiguous localization of inflamed areas; target-to-background ratios reach 22 as early as 3 h post-injection. This new detection platform could have significant clin. impact in early detection of pathologies, individual tailoring of drug therapy, and image-guided tumor resection.
Biomaterials published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C17H14N2O2, Safety of 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.
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