Vaid, Arvind published the artcileA randomized controlled trial of prophylactic sublingual misoprostol versus intramuscular methyl-ergometrine versus intramuscular 15-methyl PGF2α in active management of third stage of labor, Related Products of alcohols-buliding-blocks, the publication is Archives of Gynecology and Obstetrics (2009), 280(6), 893-897, database is CAplus and MEDLINE.
Objective: To compare the efficacy and side effects of 0.2 mg methyl-ergometrine IM, 400 μg misoprostol sublingual and 125 μg 15 Me PGF2α IM in active management of third stage of labor. Method: Two hundred low risk pregnant women with induced or spontaneous labor were randomized to receive either 400 μg misoprostol sublingually or 0.2 mg methyl-ergometrine i.m. or 125 μg 15-Me PGF2α i.m., after the delivery of anterior shoulder of baby. The main outcome measures were: blood loss more than 500 mL, need for addnl. oxytoxic drug, change in Hb level and side effects due to drugs. Results: The median estimated blood loss, blood loss more than 500 mL, need for addnl. oxytocic drug and change in Hb levels were similar in all three groups. The significant side effects in the misoprostol group were shivering, pyrexia (temperature > 38°C) and vomiting, which were self-limiting. Diarrhea was significantly more in the 15 Me PGF2α group. Three women in methyl-ergometrine group underwent manual removal of placenta. One woman in misoprostol group received blood transfusion. Conclusion: Sublingual misoprostol appears to be as effective as i.m. methyl-ergometrine and i.m. 15-Me PGF2α in the prevention of postpartum hemorrhage. It can be a good alternative in resource poor setting.
Archives of Gynecology and Obstetrics published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C5H7BO2S, Related Products of alcohols-buliding-blocks.
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