Urban, Frank J. published the artcileLipophilic 1,3-xylyl-21-crown-6 macrocyclic polyether 2-carboxylic acids as biological mimics of the ionophore antibiotics, Product Details of C14H22O2, the publication is Journal of Medicinal Chemistry (1990), 33(2), 765-71, database is CAplus and MEDLINE.
Twelve lipophilic 1,3-xylyl-21-crown-6 macrocyclic polyether 2-carboxylic acids, e.g. I (R = H, Me, PhCH2; n = 1), two lariat ether 1,3-xylyl-21-crown-6 macrocyclic polyether 2-carboxylic acids II (R1 = H, Me3C) and two 1,3-xyly-28-crown-8 macrocyclic polyether 2-carboxylic acids I (R = H, Me, n = 2) were synthesized and tested for in vitro antibacterial activity, in vitro stimulation of rumen propionic acid production, and in vivo anticoccidial activity in chickens. These are biol. screens relevant to animal health areas where the ionophore antibiotics such as monensin have found application. While the parent structure without lipophilic substituents was biol. inactive, the lipophilic macrocycles were active in the two in vitro tests but not against chicken coccidiosis. One compound I (R = Me, n = 1) was tested in cattle and was found to increase levels of propionic acid in the rumen fermentation This effect is considered an important factor for increasing the efficiency of feed utilization in cattle exhibited by the ionophore antibiotic monensin. The alkali ion salts of these lipophilic macrocyclic polyether carboxylic acids are very soluble in organic solvents and insoluble in water. These compounds are proposed to act as ion-transport agents and functional mimics of the ionophore antibiotics in the biol. systems described above.
Journal of Medicinal Chemistry published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C9H8FNO2, Product Details of C14H22O2.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts