Trawally, Muhammed published the artcileMandelic acid-based spirothiazolidinones targeting M. tuberculosis: Synthesis, in vitro and in silico investigations, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Bioorganic Chemistry (2022), 105688, database is CAplus and MEDLINE.
A series of new spirothiazolidinone derivatives with a mandelic acid moiety were synthesized and subsequently tested in growth inhibition assays against Mycobacterium tuberculosis strain H37Rv. Compound I displayed the highest inhibition value of 98% at lower than 6.25μg/mL concentration A single crystal X-ray anal. was conducted on this compound to confirm the structure and determine its absolute configuration. Afterwards, reverse docking and mol. dynamics simulations of this specific stereoisomer were performed against a selection of 10 putative targets of M. tuberculosis to suggest possible mechanisms of action. This results suggest HadAB, Pks13, DprE1, FadD32 and InhA as possible target proteins for the observed antimycobacterial activity of compound I.
Bioorganic Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C14H14, Application of 2-Hydroxy-2-phenylacetic acid.
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