Rej, Supriya published the artcileTransient Imine as a Directing Group for the Metal-Free o-C-H Borylation of Benzaldehydes, Safety of 4-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde, the publication is Journal of the American Chemical Society (2021), 143(7), 2920-2929, database is CAplus and MEDLINE.
Organoboron reagents are important synthetic intermediates and have wide applications in synthetic organic chem. The selective borylation strategies that are currently in use largely rely on the use of transition-metal catalysts. Hence, identifying much milder conditions for transition-metal-free borylation would be highly desirable. The authors herein present a unified strategy for the selective C-H borylation of electron-deficient benzaldehyde derivatives using a simple metal-free approach, using an imine transient directing group. The strategy covers a wide spectrum of reactions and (i) even highly sterically hindered C-H bonds can be borylated smoothly, (ii) despite the presence of other potential directing groups, the reaction selectively occurs at the o-C-H bond of the benzaldehyde moiety, and (iii) natural products appended to benzaldehyde derivatives can also give the appropriate borylated products. Also, the efficacy of the protocol was confirmed by the fact that the reaction proceeds even in the presence of external impurities.
Journal of the American Chemical Society published new progress about 1883607-86-0. 1883607-86-0 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester, name is 4-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde, and the molecular formula is C13H17BO4, Safety of 4-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde.
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