Prabhu, Padmavathi P. published the artcileMethod development and validation for the estimation of ambroxol HCl in pharmaceutical dosage form, Category: alcohols-buliding-blocks, the publication is International Journal of Pharmaceutical Sciences and Research (2018), 9(6), 2550-2553, database is CAplus.
Rapid, sensitive, specific and validated colorimetric methods have been developed for the quant. estimation of ambroxol HCl in bulk and dosage form. The current method was developed based on oxidation of ambroxol with Gibb’s reagent (method I) and p-diethyl amino benzaldehyde in toluene (method II). The formed intense color complex was measured at 537.2 nm and 438.4 nm resp. Under optimized exptl. conditions, Beer’s law is obeyed in concentration range 5 – 30 μg/mL for both the methods with regression co-efficient 0.9994 and 0.9992. Recovery studies were conducted by standard addition method to confirm the accuracy of the method. The LOD and LOQ for the estimation of ambroxol were found as 0.0773, 0.2343 for method I and 0.0667, 0.2021 for method II resp. The proposed method was validated as per ICH guidelines.
International Journal of Pharmaceutical Sciences and Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Category: alcohols-buliding-blocks.
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