McPherson, Alexander published the artcileSearching for silver bullets: An alternative strategy for crystallizing macromolecules, Synthetic Route of 85618-21-9, the publication is Journal of Structural Biology (2006), 156(3), 387-406, database is CAplus and MEDLINE.
Based on a hypothesis that various small mols. might establish stabilizing, intermol., non covalent crosslinks in protein crystals and thereby promote lattice formation, the authors carried out three sep. experiments The authors assessed the impact of 200 chems. on the propensity of 81 different proteins and viruses to crystallize. The experiments were comprised of 18 240 vapor diffusion trials. A salient feature of the experiments was that, aside from the inclusion of the reagent mixes, only two fundamental crystallization conditions were used, 30% PEG 3350, and 50% Tacsimate at pH 7. Overall, 65 proteins (85%) were crystallized Most significant was that 35 of the 65 (54%) crystallized only in the presence of one or more reagent mixes, but not in control samples lacking any additives. Among the most promising types of reagent mixes were those composed of polyvalent, charged groups, such as di and tri carboxylic acids, diamino compounds, mols. bearing one or more sulfonyl or phosphate groups, and a broad range of common biochems., coenzymes, biol. effectors, and ligands. The authors propose that an alternate approach to crystallizing proteins might be developed, which employs a limited set of fundamental crystallization conditions combined with a broad screen of potentially useful small mol. additives.
Journal of Structural Biology published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.
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