Harris, Sean M. published the artcileA Data Mining Approach Reveals Chemicals Detected at Higher Levels in Non-Hispanic Black Women Target Preterm Birth Genes and Pathways, HPLC of Formula: 80-09-1, the publication is Reproductive Sciences (2022), 29(7), 2001-2012, database is CAplus and MEDLINE.
Preterm birth occurs disproportionately in the USA non-Hispanic Black population. Black women also face disproportionate exposure to certain environmental chems. The goal of this study was to use publicly available toxicogenomic data to identify chem. exposures that may contribute to preterm birth disparities. We tested 19 chems. observed at higher levels in the blood or urine of non-Hispanic Black women compared to non-Hispanic White women. We obtained chem.-gene interactions from the Comparative Toxicogenomics Database and a list of genes involved in preterm birth from the Preterm Birth Database. We tested chems. for enrichment with preterm birth genes using chi-squared tests. We then conducted pathway enrichment anal. for the preterm birth genes using DAVID software and identified chem. impacts on genes involved in these pathways. Genes annotated to all 19 chems. were enriched with preterm birth genes (FDR-adjusted p value < 0.05). Preterm birth enriched chems. that were detected at the highest levels in non-Hispanic Black women included Me mercury, methylparaben, propylparaben, di-Et phthalate, dichlorodiphenyldichloroethylene, and bisphenol S. The preterm birth genes were enriched for pathways including “inflammatory response” (FDR-adjusted p value = 3 x 10-19), “aging” (FDR-adjusted p value = 4 x 10-8) and “response to estradiol” (FDR-adjusted p value = 2 x 10-4). Chems. enriched with preterm birth genes impacted genes in all three pathways. This study adds to the body of knowledge suggesting that exposures to environmental chems. contribute to racial disparities in preterm birth and that multiple chems. drive these effects. These chems. affect genes involved in biol. processes relevant to preterm birth such as inflammation, aging, and estradiol pathways.
Reproductive Sciences published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, HPLC of Formula: 80-09-1.
Referemce:
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