Braddock, D. Christopher published the artcileMethyltrimethoxysilane (MTM) as a Reagent for Direct Amidation of Carboxylic Acids, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is Organic Letters (2022), 24(5), 1175-1179, database is CAplus and MEDLINE.
Methyltrimethoxysilane [MTM, CH3Si(OMe)3] was demonstrated an effective, inexpensive, and safe reagent for direct amidation of carboxylic acids with amines. Two simple workup procedures that provided the pure amide product R1C(O)N(R2)R3 [R1 = Ph, Bn, 4-IC6H4, etc.; R2 = Me, Et, Ph, etc.; R3 = H, Me, Et, MeO; R2R3 = (CH2)5, O(CH2)4]without the need for further purification was developed. First employed an aqueous base-mediated annihilation of MTM. Second involved simple product crystallization from the reaction mixture provides a low process mass intensity direct amidation protocol.
Organic Letters published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.
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