Witty, David R. published the artcileSAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849, Formula: C10H15NO, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(18), 4865-4871, database is CAplus and MEDLINE.
We report here the discovery of a class of MCH R1 ligands based on a biphenyl carboxamide template. A docked-in model is presented indicating key interactions in the putative binding site of the receptor. Parallel high throughput synthetic techniques were utilized to allow rapid exploration of the structure-activity relationship around this template, leading to compound SB-568849 (I) which possessed good receptor affinity and selectivity. This compound proved to be an antagonist with stability in vivo, an acceptable brain-blood ratio and oral bioavailability.
Bioorganic & Medicinal Chemistry Letters published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C13H14BNO2, Formula: C10H15NO.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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