Timperley, Christopher M. published the artcileFluorinated phosphorus compounds Part 6. The synthesis of bis(fluoroalkyl) phosphites and bis(fluoroalkyl) phosphorohalidates, HPLC of Formula: 2240-88-2, the publication is Journal of Fluorine Chemistry (2002), 113(1), 65-78, database is CAplus.
Reaction of P trichloride with tert-BuOH and fluoro alcs. gave bis(fluoroalkyl) phosphites (RFO)2P(O)H in 42-89% yield, where RF = HCF2CH2, H(CF2)2CH2, H(CF2)4CH2, CF3CH2, C2F5CH2, C3F7CH2, (CF3)2CH, (FCH2)2CH, CF3Me2C, (CF3)2CH3C, CF3CH2CH2, C4F9CH2CH2 and C6F13CH2CH2. Treatment of these with Cl2 in CH2Cl2 gave the bis(fluoroalkyl) phosphorochloridates (RFO)2P(O)Cl in 49-96% yield. The chloridate (CF3CH2O)2P(O)Cl was isolated in much lower yield from the interaction of thionyl chloride with bis(trifluoroethyl) phosphite. Heating the latter in CH2Cl2 with KF and a catalytic amount of HO2CCF3 gave the corresponding fluoridate (CF3CH2O)2P(O)F in 84% yield. Treatment of bis(trifluoroethyl) phosphite with Br2 or I2 gave the bromidate (CF3CH2O)2P(O)Br and iodidate (CF3CH2O)2P(O)I in 51 and 46% yield, resp. The iodidate is the 1st dialkyl phosphoroiodidate to have been isolated and characterized properly-its discovery lags behind the 1st isolation of a dialkyl phosphorochloridate by over 130 yr. The fluoroalkyl phosphoryl compounds are generally more stable than known unfluorinated counterparts.
Journal of Fluorine Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C7H13NO2, HPLC of Formula: 2240-88-2.
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