Thanzeel, F. Yushra published the artcileClick chemistry enables quantitative chiroptical sensing of chiral compounds in protic media and complex mixtures, Application In Synthesis of 96-20-8, the publication is Nature Communications (2018), 9(1), 5323, database is CAplus and MEDLINE.
Click reactions have become powerful synthetic tools with unique applications in the health and materials sciences. Despite the progress with optical sensors that exploit the principles of dynamic covalent chem., metal coordination or supramol. assemblies, quant. anal. of complex mixtures remains challenging. Herein, we report the use of a readily available coumarin conjugate acceptor for chiroptical click chirality sensing of the absolute configuration, concentration and enantiomeric excess of several compound classes. This method has several attractive features, including wide scope, fast substrate fixation without byproduct formation or complicate equilibrium often encountered in reversible substrate binding, excellent solvent compatibility, and tolerance of air and water. The ruggedness and practicality of this approach are demonstrated by comprehensive anal. of nonracemic monoamine samples and crude asym. imine hydrogenation mixtures without work-up. Click chemosensing addresses increasingly important time efficiency, cost, labor and chem. sustainability aspects and streamlines asym. reaction development at the mg scale.
Nature Communications published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C16H12O, Application In Synthesis of 96-20-8.
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