Roy, Niloy published the artcileProbing Host-Guest inclusion complexes of Ambroxol Hydrochloride with α- & β-Cyclodextrins by physicochemical contrivance subsequently optimized by molecular modeling simulations, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Chemical Physics Letters (2020), 137372, database is CAplus.
Herein, we report the inclusion of AMB in cyclodextrins leading to host-guest assemblies. The inclusion complexes comprised of Ambroxol Hydrochloride (AMB) with α-cyclodextrin (αCD) and β-cyclodextrin (βCD) have been confirmed by exptl. (UV-vis titration, FTIR, ESI-MS, 1NMR, 2D-NMR) and computational studies (mol. docking, mol. mechanics calculation). The mol. docking studies demonstrate a better insight into geometry and inclusion mode of AMB inside αCD as well as βCD cavity. Formation of inclusion complexes with different cyclodextrins causes some structural changes of guest mols. during the encapsulation process confirmed by bond length, dihedral angle changes and dynamic simulations.
Chemical Physics Letters published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.
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