Norris, Paul C. published the artcileResolvin D3 multi-level proresolving actions are host protective during infection, Product Details of C3H6O2, the publication is Prostaglandins, Leukotrienes and Essential Fatty Acids (2018), 81-89, database is CAplus and MEDLINE.
Resolution of infection and inflammation is governed by innate immune cells. The resolvin family of n-3 mediators produced by resolving exudates stimulates clearance of neutrophils and attenuates pro-inflammatory signals. Using metabololipidomics, endogenous resolvin D3 (RvD3) was identified in self-resolving exudates during active E. coli infection. Through a new, independent synthetic route for RvD3, we matched endogenous and synthetic RvD3 and determined that RvD3 (ng doses) potently reduced the resolution interval (Ri) by ∼4.5 h during E. coli peritonitis after administration at peak inflammation (Tmax=12 h) and increased leukocyte phagocytosis of E. coli and neutrophils as well as reduced proinflammatory cytokines, chemokines, MMP-2 and MMP-9. At pM-nM concentrations, RvD3 also enhanced human macrophage efferocytosis and bacterial phagocytosis, increased neutrophil bacterial phagocytosis and intracellular ROS generation, and reduced human platelet-PMN aggregation. These results provide addnl. evidence for potent RvD3 immunoresolvent actions in host defense, host protection and antimicrobial defense.
Prostaglandins, Leukotrienes and Essential Fatty Acids published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Product Details of C3H6O2.
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