Naykodi, Pradnya S. published the artcileTaste masking of bitter drugs by using ion exchange resin method, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is World Journal of Pharmaceutical Research (2020), 9(2), 562-597, database is CAplus.
The various organoleptic properties such as taste, smell, texture also these are important factor in development of oral dosage forms. The taste is the major factor that affect the patient compliance and product quality. Acceptability of any dosage form mainly depends over its taste i.e. mouth feel. Drug mol. interact with taste receptor on the tongue to give bitter, sweet or other taste sensation, when they dissolve in saliva. The taste buds shows the sensation of taste by signal transduction from the receptor organs. Now a days most of the potent drugs that are cardiac, analgesic, anti-inflammatory, anti-tubercular, antibacterial, anthalmetics, antimalarial, antiepileptics, anticoagulants, histamine receptor agonist, antithyroids, antineoplastic, antiprotozoal, diuretics, nutritional agents, opioid analgesic, sex hormones, vaccines most of them are bitter in taste. So it become a necessary to develop such a dosage form that is acceptable for its taste by patients especially children or geriatrics. It becomes a challenge for pharmacist to make palatable formulation by masking the bitter taste of the drug.
World Journal of Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts