Luo, Huan published the artcileβ-Cyclodextrin covalent organic framework modified-cellulose acetate membranes for enantioseparation of chiral drugs, Application In Synthesis of 90-64-2, the publication is Separation and Purification Technology (2022), 120336, database is CAplus.
Membrane-based chiral separation has attracted widespread research attention. However, traditional chiral membranes remain an unbridgeable trade-off between permeability and selectivity. Chiral covalent organic frameworks (CCOFs) with inherently high porosity and intrinsic chirality are highly promising solutions Herein we report novel CCOF membranes for enantioseparation of chiral drugs. A β-cyclodextrin covalent organic framework (β-CD COF) was used as the chiral selector to fabricate two types of β-CD COF membranes by phys. and chem. modifying cellulose acetate substrates, including a β-CD COF mixed matrix membrane (β-CD COF MMM) and a β-CD COF thin film nanocomposite membrane (β-CD COF TFN). In particular, the β-CD COF TFN was the first reported interfacial polymerized COF membrane for enantioseparation and performed more preferentially than β-CD COF MMM. The optimal enantioselectivities of D, L-tryptophan (e.e% = 100%), (RS)-mandelic acid (e.e% = 58.1%), D, L-phenylalanine (e.e% = 36.3%), and (RS)-propranolol (e.e% = 18.0%) and comparable solute flux (Flux = 1.9-5.4 nmol·cm-2·h-1) were achieved using β-CD COF TFN. Benefiting from the remarkable chem. stability of β-CD COF, such membranes also had excellent thermal stability, acid resistance, and long-term storage stability. Moreover, the chiral recognition mechanism was investigated using mol. docking simulations. Fabricated membranes with high enantioseparation performance and stability provide a new perspective on establishing chiral membranes and show potential for industrial application.
Separation and Purification Technology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application In Synthesis of 90-64-2.
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