Khim, Seock-Kyu published the artcileDiscovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors, Formula: C10H9NO, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(14), 3895-3898, database is CAplus and MEDLINE.
The synthesis and biol. evaluation of a series of aryl diamines as inhibitors of LTA4 hydrolase inhibitors are described. The optimization which led to the identification of the optimal para-substitution on the di-Ph ether moiety and diamine spacer is discussed. The resulting compounds such as I have excellent enzyme and cellular potency as well as desirable pharmacokinetic properties.
Bioorganic & Medicinal Chemistry Letters published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Formula: C10H9NO.
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