Gonzalez-Correa, J. A. published the artcileProtective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Naunyn-Schmiedeberg’s Archives of Pharmacology (2005), 371(1), 81-88, database is CAplus and MEDLINE.
Triflusal is a fluorinated derivative of acetylsalicylic acid (ASA) with demonstrated antithrombotic activity. Recently, evidence for a neuroprotective effect was obtained. The aim of this study was to compare the neuroprotective effects of the main metabolite of triflusal (2-hydroxy-4-trifluoromethylbenzoic acid, HTB) and the ASA metabolite salicylic acid (SA) in an in vitro model of anoxia-reoxygenation in rat brain slices. Rat brain slices (n=10 per group) were subjected to a period of anoxia followed by 180 min reoxygenation. The authors measured oxidative stress parameters (lipid peroxidation, glutathione system), prostaglandins (PGE2), nitric oxide pathway activity (NO) (nitrites+nitrates, constitutive and inducible NO synthase activity) and LDH efflux, a biochem. marker of cell death. Various concentrations (10, 100, and 1000 μM) of triflusal, HTB, ASA, or SA were tested. Triflusal at 10, 100, and 1000 μM decreased LDH efflux in rat brain slices after anoxia/reoxygenation by 24, 35, and 49% resp. This effect was proportionately greater than that of ASA (0, 13, and 32%). The results with HTB were similar to those with triflusal, whereas SA showed a greater protective effect than ASA (13, 33, and 35%). The antioxidant effects of HTB and SA on the biochem. mechanisms of cell damage studied here were also greater than the effects of triflusal and ASA, a finding attributable mainly to the decrease in lipid peroxidation and to the ability of HTB to also increase glutathione levels. The triflusal metabolite reduced inducible NO synthase activity by 18, 21, and 30%, whereas SA inhibited this activity by 9, 17, and 23%. Triflusal and HTB led to greater increases in NO synthase than ASA or AS. In conclusion, the metabolite HTB plays an important role in the neuroprotective effect of triflusal, at least in the exptl. model of anoxia-reoxygenation tested here.
Naunyn-Schmiedeberg’s Archives of Pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.
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