Espinosa-Aguirre, J. J. published the artcileGenotoxicity of amebicide and anthelmintic drugs in Escherichia coli pol A+/pol A–, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Mutation Research, Genetic Toxicology Testing (1987), 188(2), 111-20, database is CAplus and MEDLINE.
The amebicides dehydroemetine and chloroquine and the anthelmintic pyrvinium pamoate, previously reported to be mutagenic in Salmonella typhimurium were clearly genotoxic in the Escherichia coli pol A+/pol A– assay. Two other antiparasitic drugs, diiodohydroxyquin and 4-hexylresorcinol, were also genotoxic in E. coli, while iodochlorhydroxyquin preferentially inhibited the pol A+ strain. From the 3 alternative testing methods employed, the liquid suspension succeeded in detecting 5 antiparasitic drugs as genotoxic; the microsuspension identified 2, and the disk diffusion method only 1. However, the metabolic activation system could only be coupled successfully and in a reproducible way to the microsuspension assay.
Mutation Research, Genetic Toxicology Testing published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.
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