Chihara, Yuko published the artcileSerum-resistant Gene Transfer Activity of Mannosylated Dendrimer/α-Cyclodextrin Conjugate (G3), Application In Synthesis of 96345-79-8, the publication is Journal of Inclusion Phenomena and Macrocyclic Chemistry (2006), 56(1-2), 89-93, database is CAplus.
The purpose of this study is to evaluate in vitro gene transfer activity of polyamidoamine (PAMAM) starburst dendrimer (generation 3, G3) conjugate with α-cyclodextrin (α-CDE conjugate (G3)) bearing mannose (Man-α-CDE conjugate (G3)) with the degree of substitution of the mannose moiety 10 (DSM 10) as a novel non-viral vector in NIH3T3 and HepG2 cells. Man-α-CDE conjugate (G3) was found to have much higher gene transfer activity than dendrimer and α-CDE conjugate in NIH3T3 and HepG2 cells, which are independent of the expression of cell-surface mannose receptors. Gene transfer activity of Man-α-CDE conjugate (G3) was highly serum-resistant compared to that of dendrimer and α-CDE conjugate. No cytotoxicity after transfection of the complex of pDNA with Man-α-CDE conjugate (G3) was observed and the transfection activity was much higher than Lipofectin in NIH3T3 cells. These results suggest the potential use of Man-α-CDE conjugate (G3) as a non-viral vector.
Journal of Inclusion Phenomena and Macrocyclic Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Application In Synthesis of 96345-79-8.
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