Brown, Pamela published the artcileβ-Lactamase-stable penicillins. Synthesis and structure-activity relationships of (Z)-alkyloxyimino penicillins; selection of BRL 44154, Safety of 1-Methylcyclobutan-1-ol, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1991), 881-91, database is CAplus.
A series of (Z)-2-alkyloxyimino-2-(2-aminothiazol-4-yl)acetamidopenicillins I (R = Me, Et, CHMe2, CMe3, cycloalkyl) were prepared New methodol. was developed to prepare tertiary alkyl oximes. High stability to β-lactamases and potent antibacterial activity have been achieved against Gram-pos. and certain Gram-neg. organisms. Activity against methicillin-resistant Staphylococcus aureus was an unexpected finding. BRL 44154 (I; R = cyclopentyl) has been selected for further study.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Safety of 1-Methylcyclobutan-1-ol.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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