Al Sulaiman, Dana published the artcileChemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing, Application In Synthesis of 6346-09-4, the publication is Nano Letters (2018), 18(9), 6084-6093, database is CAplus and MEDLINE.
Label-free, single-mol. sensing is an ideal candidate for biomedical applications that rely on the detection of low copy numbers in small volumes and potentially complex biofluids. Among them, solid-state nanopores can be engineered to detect single mols. of charged analytes when they are elec. driven through the nanometer-sized aperture. When successfully applied to nucleic acid sensing, fast transport in the range of 10-100 nucleotides per ns often precludes the use of standard nanopores for the detection of the smallest fragments. Herein, hydrogel-filled nanopores (HFN) are reported that combine quartz nanopipettes with biocompatible chem. poly(vinyl) alc. hydrogels engineered inhouse. Hydrogels were modified phys. or chem. to finely tune, in a predictable manner, the transport of specific mols. Controlling the hydrogel mesh size and chem. composition allowed us to slow DNA transport by 4 orders of magnitude and to detect fragments as small as 100 base pairs (bp) with nanopores larger than 20 nm at an ionic strength comparable to physiol. conditions. Considering the emergence of cell-free nucleic acids as blood biomarkers for cancer diagnostics or prenatal testing, the successful sensing and size profiling of DNA fragments ranging from 100 bp to >1 kbp long under physiol. conditions demonstrates the potential of HFNs as a new generation of powerful and easily tunable mol. diagnostics tools.
Nano Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application In Synthesis of 6346-09-4.
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