Month: November 2022

Zhang, Jun-Hui; Xie, Sheng-Ming; Wang, Bang-Jin; He, Pin-Gang; Yuan, Li-Ming published an article in 2018, the title of the article was A homochiral porous organic cage with large cavity and pore windows for the efficient gas chromatography separation of enantiomers and positional isomers.COA of Formula: C8H9NO3 And the article contains the following content:

Porous organic cages composed of discrete cage mols. have attracted considerable recent attention as gas adsorption materials and separation media. The authors report a homochiral porous organic cage CC5 with a large cavity and pore windows as a novel stationary phase for high-resolution gas chromatog. separations The capillary column was prepared by a static coating method. A large number of racemic compounds were resolved on the coated capillary column, including derivatized amino acids, alcs., alc. amines, esters, ethers, ketones, and epoxides. It is interesting that the CC5-coated capillary column exhibits significant chiral recognition complementarity to a com. β-DEX 120 column and a previously reported homochiral porous organic cage CC3-R-coated column, which could expand the range of the analytes amenable to separation on porous organic cage-based capillary columns. Also, the fabricated column also shows excellent selectivity for the separation of positional isomers, including the challenging ethylbenzene and xylene isomers. Exptl. results demonstrate an excellent separation performance and stability of the CC5-coated column, making it promising for gas chromatog. applications. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).COA of Formula: C8H9NO3

The Article related to homochiral porous organic cage large cavity efficient gas chromatog, gas chromatog enantiomer positional isomer separation, chiral separation, gas chromatography, homochiral porous organic cages, positional isomers, stationary phases and other aspects.COA of Formula: C8H9NO3

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On June 2, 2017, Vara, Brandon A.; Patel, Niki R.; Molander, Gary A. published an article.Related Products of 386704-04-7 The title of the article was O-Benzyl Xanthate Esters under Ni/Photoredox Dual Catalysis: Selective Radical Generation and Csp3-Csp2 Cross-Coupling. And the article contained the following:

Alkyl xanthate esters are perhaps best known for their use in deoxygenation chem. However, their use in cross-coupling chem. has not been productive, which is due, in part, to inadequate xanthate activation strategies. Herein, we report the use of O-benzyl xanthate esters, readily derived from alcs., as radical pronucleophiles in Csp3-Csp2 cross-couplings under Ni/photoredox dual catalysis. Xanthate (C-O) cleavage is found to be reliant on photogenerated (sec-butyl) radical activators to form new carbon-centered radicals primed for nickel-catalyzed cross-couplings. Mechanistic experiments support the fact that the key radical components are formed independently, and relative rates are carefully orchestrated, such that no cross reactivity is observed The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Related Products of 386704-04-7

The Article related to cross coupling benzyl xanthate ester nickel photoredox dual catalysis, radical generation xanthate cross coupling, alkyl xanthate esters, carbon-centered radicals, cross-coupling, metal-catalyzed reactions, selective radical generation and other aspects.Related Products of 386704-04-7

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On August 3, 2022, Tziotzi, Thomais G.; Mavromagoulos, Athanasios; Murrie, Mark; Dalgarno, Scott J.; Evangelisti, Marco; Brechin, Euan K.; Milios, Constantinos J. published an article.Electric Literature of 4719-04-4 The title of the article was Constructing “Closed” and “Open” {Mn8} Clusters. And the article contained the following:

Use of the 1,3,5-tri(2-hydroxyethyl)-1,3,5-triazacyclohexane ligand, LH3, in manganese chem. affords access to two structurally related {Mn8} clusters: a “closed” {MnIII6MnII2} puckered square wheel of formula [Mn8L2(LH)O3(OH)2(MeO)2Br(ImH)(H2O)3](Br)3 (1; imH = imidazole) and an “open” {MnIII8} rod of formula [MnIII8L2O4(aibH)2(aib)2(MeO)6(MeOH)2](NO3)2 (2, aibH = 2-amino-isobutyric acid). In each case the triaza ligands, L/LH, direct the formation of {Mn3} triangles with their N atoms preferentially bonding to the Jahn-Teller axes of the MnIII ions. Subsequent self-assembly is dependent on the anion of the Mn salt and the identity of the organic coligand employed-the terminally bonded imidazole and the chelating/bridging amino acid. The {Mn3} triangles fold up on themselves in 1, forming a wheel. However, the syn, syn-bridging carboxylates in 2 prevent this from happening, instead directing the formation of a linear rod. Magnetic susceptibility and magnetization measurements reveal competing ferro- and antiferromagnetic interactions in both complexes, the exchange being somewhat weaker in 1 due to the presence of MnII ions. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Electric Literature of 4719-04-4

The Article related to preparation closed open manganese trihydroxyethyltriazacyclohexane cluster, crystal structure closed open manganese trihydroxyethyltriazacyclohexane cluster, magnetic property closed open manganese trihydroxyethyltriazacyclohexane cluster and other aspects.Electric Literature of 4719-04-4

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On June 1, 2022, Ilhan, Zehra Esra; Brochard, Vincent; Lapaque, Nicolas; Auvin, Stephane; Lepage, Patricia published an article.Electric Literature of 585-88-6 The title of the article was Exposure to anti-seizure medications impact growth of gut bacterial species and subsequent host response. And the article contained the following:

Anti-seizure medications (ASMs) are the first line of treatment for seizure control in children with epilepsy. Cumulative evidence suggests an imbalanced gut microbiota in refractory epilepsy patients. We systematically investigated the differential antimicrobial impacts of nine ASM active ingredients, seven common excipients of ASMs, and four syrup formulations on core early-life gut microbiota strains. Addnl., we evaluated the toxicity and gene expression profiles of HT-29 colon epithelial cells when exposed to active ingredients with or without bacterial supernatants. The physicochem. structure of ASM active ingredients and bacterial phylogeny were found to be related to ASM toxicity. Carbamazepine, lamotrigine, and topiramate reduced the growth of more than ten strains along with syrup excipient propyl-paraben. Various artificial sweeteners present in ASM formulations stimulated the growth of gut bacterial strains. The active ingredients that were more toxic to bacterial strains also exhibited toxicity towards HT-29 cells, yet Bifidobacterium longum supernatant reduced cytotoxic effects of carbamazepine and lamotrigine. Akkermansia muciniphila or mixed community supernatants reduced the expression of drug resistance genes in HT-29 cell lines. In summary, our results indicate that several ASM active ingredients and their excipients regulate the growth of gut bacterial strains in a species-specific manner. Interactions between ASMs and gut epithelial cells might be modulated by gut microbial metabolites. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Electric Literature of 585-88-6

The Article related to carbamazepine lamotrigine topiramate antiseizure agent gut bacteria epilepsy, anaerobic metabolism, antiepileptic drugs, drug formulations, epilepsy, intestinal epithelial cells, microbiome, parabens, pharmaco-resistance, seizures, toxicity and other aspects.Electric Literature of 585-88-6

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Yuan, Li-Ming; Ma, Wei; Xu, Mei; Zhao, Hui-Lin; Li, Yuan-Yuan; Wang, Rui-Lin; Duan, Ai-Hong; Ai, Ping; Chen, Xue-Xian published an article in 2017, the title of the article was Optical resolution and mechanism using enantioselective cellulose, sodium alginate and hydroxypropyl-β-cyclodextrin membranes.Computed Properties of 32462-30-9 And the article contains the following content:

Chiral solid membranes of cellulose, sodium alginate, and hydroxypropyl-β-cyclodextrin were prepared for chiral dialysis separations After optimizing the membrane material concentrations, the membrane preparation conditions and the feed concentrations, enantiomeric excesses of 89.1%, 42.6%, and 59.1% were obtained for mandelic acid on the cellulose membrane, p-hydroxy phenylglycine on the sodium alginate membrane, and p-hydroxy phenylglycine on the hydroxypropyl-β-cyclodextrin membrane, resp. To study the optical resolution mechanism, chiral discrimination by membrane adsorption, solid phase extraction, membrane chromatog., high-pressure liquid chromatog. ultrafiltration were performed. All of the exptl. results showed that the first adsorbed enantiomer was not the enantiomer that first permeated the membrane. The crystal structures of mandelic acid and p-hydroxy phenylglycine are the racematic compounds We suggest that the chiral separation mechanism of the solid membrane is “adsorption – association – diffusion,” which is able to explain the optical resolution of the enantioselective membrane. This is also the first report in which solid membranes of sodium alginate and hydroxypropyl-β-cyclodextrin were used in the chiral separation of p-hydroxy phenylglycine. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Computed Properties of 32462-30-9

The Article related to chiral separation enantioselectivity cellulose sodium alginate hydroxypropyl beta cyclodextrin, cellulose, chiral separation, enantioselective membrane, hydroxypropyl-β-cyclodextrin, optical resolution mechanism of membrane, sodium alginate and other aspects.Computed Properties of 32462-30-9

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On April 3, 2008, Johansson, Rolf; Karlstroem, Sofia; Kers, Annika; Nordvall, Gunnar; Rein, Tobias; Slivo, Can published a patent.Synthetic Route of 87674-15-5 The title of the patent was Preparation of [(pyridinyl)ethyl]thio[(hydroxymethyl)alkyl]amino[1,3]thiazolo[4,5-d]pyrimidinone derivatives for use as therapeutic agents. And the patent contained the following:

Title compounds I [R1 = Me or CF3; R2 = halo, CN, or alkyl; R3 and R4 independently = H or Me; n = 0 to 2], and their pharmaceutically acceptable salts, are prepared and disclosed as therapeutic agents. Thus, e.g., II was prepared by oxidation of (2R)-2-[[5-[[(1S)-1-(5-chloropyridin-2-yl)ethyl]thio]-2-methoxy[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol (preparation given). Select I were evaluated in recombinant human fractalkine hCX3CR1 binding assay, e.g., II demonstrated a Ki value of 5.8 (nM). Title compounds I are disclosed as therapeutic agents of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain. The experimental process involved the reaction of 1-(3-Fluoropyridin-4-yl)ethanol(cas: 87674-15-5).Synthetic Route of 87674-15-5

The Article related to pyrimidinone pyridinylethylthio hydroxymethylalkylamino thiazolo derivative preparation nervous system disease, pyridinylethylthio hydroxymethylalkylamino thiazolopyrimidinone derivative preparation atherosclerosis multiple sclerosis asthma and other aspects.Synthetic Route of 87674-15-5

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On April 30, 2021, Velikorodov, A. V.; Stepkina, N. N.; Osipova, V. P.; Zukhairaeva, A. S.; Shustova, E. A. published an article.HPLC of Formula: 96-76-4 The title of the article was Synthesis of New Functionally Substituted Indenes, Benzofurans and 2,5-Benzodiazocin-1(2H)-ones. And the article contained the following:

The synthesis of new functionally substituted 1H-indene-1,3(2H)-diones, such as I [R = pyridin-2-yl, morpholin-4-yl] indenobenzofurans II [R1 = 1-adamantyl, t-Bu; R2 = Me, t-Bu] and 2,5-benzodiazocines III [R3 = H, t-Bu, NHCO2Me, 1-adamantyl; R4 = H, NHCO2Me; R5 = H, Me, t-Bu, NHCO2Me] was described. The condensations of ninhydrin in concentrated sulfuric acid with 2-(morpholin-4-yl)ethyl and 2-(pyridin-2-yl)ethyl phenylcarbamates at 20°C and with 2,6-di-tert-butylphenol while gradually raising temperature from 0 to 20°C gave corresponding 2,2-disubstituted 1H-indene-1,3(2H)-diones such as I in 62-89% yields. The indeno[1,2-b]benzofuran derivatives II were obtained with high yields (96-98%) by heating ninhydrin with 2-(1-adamantyl)-4-methylphenol and 2,4-di(tert-butyl)phenol, resp., in glacial acetic acid at 60°C. Benzofurans containing an adamantyl, tert-Bu, or carbamate fragment reacted with 99% ethylenediamine at 20°C to afford 80-85% of new 2,5-benzodiazocine derivatives III. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).HPLC of Formula: 96-76-4

The Article related to disubstituted indene dione preparation, phenylcarbamate ninhydrin sulfuric acid condensation, indenobenzofuran preparation, ninhydrin phenol acetic acid condensation, benzodiazocine preparation, ethylenediamine indenobenzofuran condensation and other aspects.HPLC of Formula: 96-76-4

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On April 15, 2010, Etoga, Jean-Louis G.; Ahmed, S. Kaleem; Patel, Sarjubhai; Bridges, Richard J.; Thompson, Charles M. published an article.Recommanded Product: 32462-30-9 The title of the article was Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system Xc- over the vesicular glutamate transporter. And the article contained the following:

A panel of amino acid analogs and conformationally-restricted amino acids bearing a sulfonic acid were synthesized and tested for their ability to preferentially inhibit the obligate cysteine-glutamate transporter system X-c vs. the vesicular glutamate transporter (VGLUT). Several promising candidate mols. were identified: R/S-4-[4′-carboxyphenyl]-phenylglycine, a biphenyl substituted analog of 4-carboxyphenylglycine and 2-thiopheneglycine-5-sulfonic acid both of which reduced glutamate uptake at system X-c – by 70-75% while having modest to no effect on glutamate uptake at VGLUT. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: 32462-30-9

The Article related to glutamate uptake vglut inhibitor amino acid preparation, vesicular glutamate transporter inhibiting structure activity amino acid, phenylglycine aminothiophene sulfonic acid analog preparation, amino acid hydrolysis sulfonation sulfuric acid and other aspects.Recommanded Product: 32462-30-9

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Nesterova, Oksana V.; Nesterov, Dmytro S.; Vranovicova, Beata; Boca, Roman; Pombeiro, Armando J. L. published an article in 2018, the title of the article was Heterometallic CuIIFeIII and CuIIMnIII alkoxo-bridged complexes revealing a rare hexanuclear M6(μ-X)7(μ3-X)2 molecular core.Product Details of 2160-93-2 And the article contains the following content:

The novel hexanuclear complexes [Cu4Fe2(OH)(Piv)4(tBuDea)4Cl]·0.5CH3CN (1) and [Cu4Mn2(OH)(Piv)4(tBuDea)4Cl] (2) were prepared through one-pot self-assembly reactions of copper powder and iron(II) or manganese(II) chloride with N-tert-butyldiethanolamine (H2tBuDea) and pivalic acid (HPiv) in acetonitrile. Crystallog. studies revealed the uncommon mol. core type M6(μ-X)7(μ3-X)2 in 1 and 2, which can be viewed as a combination of two trimetallic M3(μ-X)2(μ3-X) fragments joined by three bridging atoms. The anal. and classification of the hexanuclear complexes having a M3(μ-X)2(μ3-X) moiety as a core forming fragment using data from the Cambridge Structural Database (CSD) were performed. Variable-temperature (1.8-300 K) magnetic susceptibility measurements of 1 showed a decrease of the effective magnetic moment value at low temperature, indicative of antiferromagnetic coupling between the magnetic centers (JFe-Cu/hc = -6.9 cm-1, JCu-Cu/hc = -4.1 cm-1, JFe-Fe/hc = -24.2 cm-1). Complex 1 acts as a catalyst in the reaction of mild oxidation of cyclohexane with H2O2, showing the yields of products, cyclohexanol and cyclohexanone, up to 17% using pyrazinecarboxylic acid as a promoter. In the oxidation of cis-1,2-dimethylcyclohexane with m-chloroperoxybenzoic acid (m-CPBA), 70% of retention of stereoconfiguration was observed for tertiary alcs. Compound 1 also catalyzes the amidation of cyclohexane with benzamide. In all three catalytic reactions the byproducts were investigated in detail and discussed. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Product Details of 2160-93-2

The Article related to copper iron manganese alkoxo butyldiethanolamine pivalate complex preparation magnetism, oxidation catalyst copper iron manganese alkoxo butyldiethanolamine pivalate, crystal structure copper iron manganese alkoxo butyldiethanolamine pivalate and other aspects.Product Details of 2160-93-2

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Pagano, Sandro; Montana, Giuseppe; Wickleder, Claudia; Schnick, Wolfgang published an article in 2009, the title of the article was Urea Route to Homoleptic Cyanates-Characterization and Luminescence Properties of [M(OCN)2(urea)] and M(OCN)2 with M = Sr, Eu.Safety of 2-Methyl-2-propylpropane-1,3-diol And the article contains the following content:

A novel approach for the synthesis of urea complexes and homoleptic cyanates of alk. earth metals and Eu is described. The compounds were fully characterized, including their magnetism and temperature-dependent luminescence properties. A novel approach for the synthesis of urea complexes and homoleptic cyanates of alk. earth metals and Eu is described. Direct reaction of urea with elemental Sr or Eu in closed ampuls at temperatures >120° yields [M(OCN)2(urea)] with M = Sr, Eu. According to single-crystal x-ray diffraction, the isotypic complexes exhibit a layer structure ([Eu(OCN)2(urea)]: space group P21/c, a 7.826(2), b 7.130(1), c 12.916(3) Å, β 99.76(3)°, Z = 4). Also, they were characterized by vibrational spectroscopy, thermal anal., magnetic measurements, and photoluminescence studies. Thermal treatment of [M(OCN)2(urea)] to 160-240° affords evaporation of urea and the subsequent formation of solvent-free homoleptic cyanates of Sr and Eu. The crystal structures of Sr(OCN)2 and Eu(OCN)2 were determined from x-ray powder diffraction data and refined by the Rietveld method. Both compounds crystallize in the orthorhombic space group Fddd and adopt the Sr(N3)2 type structure (Sr(OCN)2: a 6.1510(4), b 11.268(1), c 11.848(1) Å; Eu(OCN)2: a 6.1514(6), b 11.2863(12), c 11.8201(12) Å). The cyanates are stable up to 450°. Above 500° β-Sr(CN)2 and Eu2O2(CN)2 are formed. Excitation and emission spectra of [Eu(OCN)2(urea)], [Sr(OCN)2(urea)]:Eu2+, Eu(OCN)2, Sr(OCN)2:Eu2+ at different temperatures are reported. A strong green emission for all examined Eu-containing compounds due to a 4f6 5d1-4f7 transition is observed at low temperatures The luminescence properties are discussed in detail and are comparable to those of thiocyanates. Compared to the latter, a blue shift of the emission bands is observed due to the higher ionicity. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Safety of 2-Methyl-2-propylpropane-1,3-diol

The Article related to europium cyanate urea complex preparation structure thermal decomposition, strontium cyanate urea complex preparation thermal decomposition, luminescence europium cyanate urea complex, crystal structure europium strontium cyanate urea complex and other aspects.Safety of 2-Methyl-2-propylpropane-1,3-diol

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