Month: November 2022

On April 16, 2022, Wang, Yixuan; Li, Hui; Li, Xiaozhen; Wang, Chenxi; Li, Qianhong; Xu, Meng; Guan, Xiangluo; Lan, Zhenghui; Ni, Yongqing; Zhang, Yan published an article.Synthetic Route of 621-37-4 The title of the article was Widely targeted metabolomics analysis of enriched secondary metabolites and determination of their corresponding antioxidant activities in Elaeagnus angustifolia var. orientalis (L.)Kuntze fruit juice enhanced by Bifidobacterium animalis subsp. Lactis HN-3 fermentation. And the article contained the following:

Elaeagnus angustifolia var. orientalis (L.)Kuntze fruit contains a large number of naturally occurring mols. present as glycoside, methylated, and Me ester conjugates, which should be hydolyzed or transformed to become bioactive forms. For this purpose, Bifidobacterium animalis subsp. lactis HN-3 was selected to ferment Elaeagnus angustifolia var. orientalis (L.)Kuntze fruit juice (EOJ). After fermentation, the total phenolic content (TPC) and antioxidant capacity of the EOJ increased significantly compared to the non-fermented EOJ. Using widely-targeted metabolomics anal., polyphenolic compounds involved in the flavonoid biosynthetic pathway were determined to be up-regulated in the fermented EOJ. In addition, the metabolites generated by 8 deglycosidation, 5 demethylation, 5 hydrogenation, and 28 other reactions were detected in higher concentrations in the fermented EOJ compared to the non-fermented EOJ. Interestingly, these up-regulated metabolites have higher antioxidant and other biol. activities than their metabolic precursors, which provide a theor. basis for the development of Bifidobacterium-fermented plant products with stronger functional activities. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Synthetic Route of 621-37-4

The Article related to elaeagnus bifidobacterium fruit juice antioxidant secondary metabolites metabolomics, antioxidant activity, elaeagnus angustifolia var. orientalis(l.)kuntze, material transformation, widely-targeted metabolomic analysis and other aspects.Synthetic Route of 621-37-4

Referemce:
Alcohol – Wikipedia,
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On February 24, 2018, Shi, Ya-Jing; Song, Hui-Hua published an article.Safety of H-Phg(4-OH)-OH The title of the article was Three enantiomeric pairs of zinc(II) homochiral coordination compounds based on D-(-)- and L-(+)-4-Hydroxyphenylglycine: Synthesis, structures and luminescent properties. And the article contained the following:

Three enantiomeric pairs of novel homochiral coordination compounds (HCCs) with the formula {[Zn(D-hpg)(4,4′-bipy)(H2O)]·(NO3)}n 1-D, {[Zn(L-hpg)(4,4′-bipy)(H2O)]·(NO3)}n 1-L, {[Zn(D-hpg)(4,4′-bipy)(H2O)]·(ClO4)}n 2-D, {[Zn(L-hpg)(4,4′-bipy)(H2O)]·(ClO4)}n 2-L, [Zn(D-hpg)2(4,4′-bipy)]·(4,4′-bipy)·2H2O 3-D, [Zn(L-hpg)2(4,4′-bipy)]·(4,4′-bipy)·2H2O 3-L (D-Hhpg = D-(-)-4-Hydroxyphenylglycine, L-Hhpg = L-(+)-4-Hydroxyphenylglycine, 4,4′-bipy = 4,4′-bipyridine) have been synthesized and characterized by single-crystal X-ray diffraction, elemental anal., IR spectroscopy, thermal anal. and powder X-ray diffraction. Compounds 1 and 2 are isostructural 2D layer structures with NO-3 or ClO-4 anions between the layers. While compound 3 features a 0D structure without counter anions. Compounds 1-D and 2-D both contain 1D right-hand helical chains via D-Hhpg ligand, while 1-L and 2-L both contain 1D left-hand helical chains via L-Hhpg ligand. It’s worth noting that 3-D forms left-hand supramol. double helical chains, while 3-L forms right-hand supramol. double helical chains. Compounds 1-3 are further extended into 3D supramol. architectures through hydrogen-bonding interactions. CD and luminescent properties of compounds 1-3 were investigated at room temperature Our results highlight that chiral ligands have an important effect on regulating the chirality/helicity of complexes and the frameworks can be controlled via applying different zinc salts and adjusting the pH values. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to zinc hydroxyphenylglycine bipyridine polymer preparation homochiral luminescence cd spectra, thermal stability zinc hydroxyphenylglycine bipyridine polymer, crystal structure zinc hydroxyphenylglycine bipyridine polymer and other aspects.Safety of H-Phg(4-OH)-OH

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Alcohol – Wikipedia,
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On July 18, 2014, Bentley, Keith W.; Wolf, Christian published an article.Recommanded Product: H-Phg(4-OH)-OH The title of the article was Comprehensive Chirality Sensing: Development of Stereodynamic Probes with a Dual (Chir)optical Response. And the article contained the following:

The attachment of a salicylaldehyde ring and a cofacial aryl or heteroaryl N-oxide chromophore onto a naphthalene scaffold affords stereodynamic probes designed to rapidly bind amines, amino alcs., or amino acids and to translate this binding event via substrate-to-receptor chirality amplification into a dual (chir)optical response. 1-(3′-Formyl-4′-hydroxyphenyl)-8-(9′-anthryl)naphthalene (1) was prepared via two consecutive Suzuki cross-coupling reactions, and the three-dimensional structure and racemization kinetics were studied by crystallog. and dynamic HPLC. This probe proved successful for chirality sensing of several compounds, but in situ IR monitoring of the condensation reaction between the salicylaldehyde moiety in 1 and phenylglycinol showed that the imine formation takes 2 h. Optimization of the substrate binding rate and the CD and fluorescence readouts led to the replacement of anthracene with smaller fluorophores capable of intramol. hydrogen bonding. 1-(3′-Formyl-4′-methoxyphenyl)-8-(4′-isoquinolyl)naphthalene N-oxide (2) and its pyridyl analog 3 combine fast substrate binding with distinctive chiral amplification. This asym. transformation of the 1st kind prompts CD and fluorescence responses that can be used for in situ determination of the absolute configuration, ee, and total concentration of many compounds The general utility of the three chemosensors was successfully tested on 18 substrates. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH

The Article related to amine chirality sensing stereodynamic probe dual chiroptical response, amino alc chirality sensing stereodynamic probe dual chiroptical response, acid amino chirality sensing stereodynamic probe dual chiroptical response and other aspects.Recommanded Product: H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 31, 2022, Aydinli, Serdar Goksin; Bulut, Elif; Deniz, Nahide Gulsah; Sayil, Cigdem; Komarovska-Porokhnyavets, Olena; Lubenets, Vira; Zvarych, Viktor; Stasevych, Maryna; Nesterkina, Mariia; Kravchenko, Iryna published an article.Quality Control of 1-Decanethiol The title of the article was New Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities. And the article contained the following:

The ketene dithioacetal 3 generated from 2-nitroperchlorobutadiene 1 reacted with various heterocyclic amines and aliphatic, aromatic and heterocyclic thiols to produce functionalized new ketene-N,S,S-acetals and S,S,S-acetals 4a-f, 5a-h as heterocyclic dithiolanes. They were separated/purified by chromatog. methods and their exact structure characterization were made clear by spectroscopic methods. These compounds synthesized could act as effective drugs for versatile activity. Evaluation of the antimicrobial effect of the obtained substances determined derivatives 4e and 5h, which have MIC=15.6 μg/mL for the test culture of Mycobacterium luteum bacteria closing to the control drug Vancomycin. The obtained compounds can be proposed as a promising synthetic objects for future mol. design to enhance the antimicrobial action. Ketene dithioacetals 3, 4a, 4b, 4e, 5g (50 mg/kg) exhibited antiseizure effect comparable with reference drug (valproic acid) on the model of pentylenetetrazole-induced convulsions after single oral administration both at 3 h and 24 h. Furthermore, tested dithioacetals possessed prolonged antidepressant activity in forced swim test (FST) considerable decreasing the duration of immobility time compared to reference drug amitriptyline. This is the first study of the investigation of anticonvulsant and antidepressant activities of ketene dithioacetals. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Quality Control of 1-Decanethiol

The Article related to ketene dithioacetals nitroperchlorobutadiene antibacterial antifungal anticonvulsant antidepressant activity, antibacterial activity, anticonvulsant action, antidepressant effect, antifungal activity, ketene dithioacetal and other aspects.Quality Control of 1-Decanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 17, 2004, Gunawardana, Indrani W. published a patent.Computed Properties of 280752-78-5 The title of the patent was Preparation of 2- or 4-(phenylthio)cinnamides as cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds. And the patent contained the following:

The title compounds (I) [wherein R1-R5 = independently H, halo, (halo)alkyl, alkoxy, cyano, NO2, CHO, and least one of R1 or R3 is an (un)substituted cis- or trans-cinnamide; Ar = (un)substituted (hetero)aryl] were prepared as cell adhesion inhibitors for the treatment of inflammatory and immune diseases and cerebral vasospasm. Examples include syntheses for 445 invention compounds and data for 3 bioassays. For instance, a mixture of 2-[(2,4-dichlorophenyl)thio]benzaldehyde (preparation given), malonic acid, piperidine in anhydrous pyridine was heated at 110°C for 2 h and then treated with aqueous HCl to give trans-2-[(2,4-dichlorophenyl)thio]cinnamic acid (91%). Conversion to the acid chloride followed by amidation with 6-amino-1-hexanol gave (E)-II (90%). In an integrin LFA-1/ICAM-1 biochem. interaction assay, I demonstrated inhibition at 4 μM. In cell-based adhesion assays which measure the ability of test compounds to block adherence of JY-8 cells (a human EBV-transformed B cell line expressing LFA-1 on its surface) to immobilized ICAM-1 or ICAM-3, I exhibited blocking activity at 4 μM and 0.6 μM, resp. The pharmaceutical composition comprising the compound I is claimed. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Computed Properties of 280752-78-5

The Article related to phenylthio cinnamide preparation cell adhesion inhibitor, aminocarbonylethenylphenyl phenyl sulfide preparation antiinflammatory immunosuppressant, cerebral vasospasm sulfide aminocarbonylethenylphenyl phenyl preparation and other aspects.Computed Properties of 280752-78-5

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Alcohol – Wikipedia,
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On September 30, 2004, Goble, Stephen D.; Pasternak, Alexander; Mills, Sander G.; Zhou, Changyou; Yang, Lihu published a patent.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Preparation of (tetrahydropyranylamino)cyclopentanecarbonyl-substituted fused azaheterocycles as modulators of cytokine receptors such as CCR2. And the patent contained the following:

Compounds I [A = R82C, C(:O), NR8, O; B = R22C, O, S(:O), SO2, NSO2R14, NC(:O)R13, NC(:O)NR122,C(:O); D, X = C, N; E = (CH2)n; G = CH:CH, CH2CH2; Y = O, R12N, S, S(:O), SO2, R112C, etc.; n = 0-2; R1 = H, NC, (un)substituted alkyl, heterocyclyl, Ph, R122N, R13C(:O)N(R12), R14SO2N(R12), R11C(:O), R122NC(:O); R2 = H, alkyl, F, HO, heterocyclyl, R13C(:O)NH, etc.; R3, R4 = absent, H, (un)substituted alkyl, HO, Cl, O, etc.; R5 = (un)substituted alkyl, alkoxy, alkylcarbonyl, alkylthio, pyridyl, etc.; R8 = H, alkyl, (un)substituted alkylcarbonylalkyl; R11 = HO, H, (un)substituted alkyl, alkoxy, cycloalkyl, benzyl, phenyl; R12 = H, (un)substituted alkyl, benzyl, Ph, cycloalkyl; R13 = H, (un)substituted alkyl, alkoxy, benzyl, Ph, cycloalkyl; R14 = H, HO, (un)substituted alkyl, benzyl, Ph, cycloalkyl; R15 = H, (un)substituted alkyl; R16 = H, (un)substituted alkyl, alkoxy, cycloalkyl, F, HO, etc.; R17 = H, HO, (un)substituted alkyl, alkoxy, R11C(:O); R18 = H, F, (un)substituted alkyl, cycloalkoxy, alkoxy; R16 and either R17 or R18 may be joined in a ring] such as II are prepared as modulators of cytokine receptors such as CCR2 for the treatment of inflammatory and immune system disorders such as rheumatoid arthritis. Coupling of (tert-butoxy)(trifluoromethyl)benzylamine III and nonracemic (tetrahydropyranylamino)cyclopentanecarboxylic acid IV followed by cleavage of the tert-Bu group, cyclocondensation with paraformaldehyde, and cleavage of the trifluoroacetamide yields II as its hydrochloride salt. III is prepared by nucleophilic substitution of 2-fluoro-5-(trifluoromethyl)benzonitrile with potassium tert-butoxide followed by hydrogenation of the nitrile moiety. IV is prepared by Boc protection of the amine moiety of V, benzylation of the carboxylic acid group, cleavage of the Boc group, reductive amination of the amine with tetrahydropyran-4-one, trifluoroacetylation of the secondary amine, stereoselective alkylation of the ester with potassium bis(trimethylsilyl)amide and iso-Pr iodide, and hydrogenolysis of the benzyl ester; a second route to IV is also described. Compounds of the invention inhibit CCR2 with IC50 values of < 1 μM (no data). The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to tetrahydropyranylamino cyclopentanecarbonyl substituted fused azaheterocycle preparation cytokine receptor modulator, ccr2 modulator tetrahydropyranylamino cyclopentanecarbonyl substituted fused azaheterocycle preparation and other aspects.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

Referemce:
Alcohol – Wikipedia,
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On April 7, 2020, Grashow, Rachel; Bessonneau, Vincent; Gerona, Roy R.; Wang, Aolin; Trowbridge, Jessica; Lin, Thomas; Buren, Heather; Rudel, Ruthann A.; Morello-Frosch, Rachel published an article.Electric Literature of 96-76-4 The title of the article was Integrating Exposure Knowledge and Serum Suspect Screening as a New Approach to Biomonitoring: An Application in Firefighters and Office Workers. And the article contained the following:

Firefighters (FF) are exposed to recognized and probable carcinogens, yet there are few chem. exposure studies and associated health concerns for women firefighters, e.g., breast cancer. Biomonitoring often requires a-priori selection of compounds to be measured, and may not detect relevant, lesser known, exposures. The women firefighters biomonitoring collaborative (WFBC) created a biol. sample archive and conducted a general suspect screen (GSS) to address this data gap. Using liquid chromatog./quadrupole time-of-flight tandem mass spectrometry, candidate chems. of interest were identified in serum samples from 83 women (FF) and 79 women office workers (OW) in San Francisco, California. Chem. peaks were identified by matching accurate mass from serum samples to a custom chem. database of 722 slightly polar phenolic and acidic compounds, including many relevant to firefighting or breast cancer etiol. Collected tentatively identified chems. were selected for confirmation based on: detection frequency or peak area differences between OW and FF; evidence of mammary carcinogenicity, estrogenicity, or genotoxicity; and not currently measured in large biomonitoring studies. In total 620 chems. were detected which matched 300 mol. formulas in the WFBC database, including phthalate and phosphate flame retardant metabolites, phenols, pesticides, nitro- and nitroso-compounds, and per- and polyfluoroalkyl substances. Of 20 suspect chems. selected for validation, eight were confirmed (two alkylphenols, Et paraben, BPF, PFOSAA, benzophenone-3, benzyl p-hydroxybenzoate, tri-Ph phosphate) by running a matrix spike of reference standards and using m/z, retention time, and the confirmation of at least two fragment ions as matching criteria. GSS provided a powerful high-throughput approach to identify and prioritize novel chems. for biomonitoring and health studies. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Electric Literature of 96-76-4

The Article related to occupational health hazard women firefighter office worker chem exposure, risk assessment women firefighter office worker cancer chem exposure, carcinogen understudied compound biomonitoring women firefighter office worker and other aspects.Electric Literature of 96-76-4

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Alcohol – Wikipedia,
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On October 2, 2014, Ebert, Sophia; Ludolph, Bjoern; Wigbers, Christof Wilhelm; Maas, Steffen; Huelskoetter, Frank; Scialla, Stefano; Boeckh, Dieter; Christmas, Kevin; Eichstadt Waun, Amy; Loughnane, Brian J.; Rees, Darren; Eidamshaus, Christian published a patent.COA of Formula: C7H16O2 The title of the patent was Aminated polyoxyalkylated 1,3-diols. And the patent contained the following:

Aminated C2-18-alkoxylated 1,3-diols compounds, such as aminated polypropoxylated 2-butyl-2-ethyl-1,3-propanediol (I), with d.p. 2-200 are manufactured for use as grease removers in laundry detergents and curing agents for epoxy resins. Thus, 322.6 g I was propoxylated with 467.8 g propylene oxide at 140° in the presence of KOH and aminated (600 g) 18 h with 1500 g NH3 in the presence of a metal catalyst at 205° and 270 bar pressure. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).COA of Formula: C7H16O2

The Article related to aminated alkoxylated diol grease removal additive laundry detergent, epoxy resin curing agent aminated alkoxylated diol, butylethylpropanediol polypropoxylated aminated manufacture grease removal additive laundry detergent and other aspects.COA of Formula: C7H16O2

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On September 30, 2001, Lysenko, I. L.; Kulinkovich, O. G. published an article.Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol The title of the article was A convenient procedure for preparation of 1-(1-aminoalkyl)-1-cyclopropanols from N-benzyl α-amino acid esters. And the article contained the following:

The reaction of N-benzyl α-amino acid Et esters, e.g. I, with ethylmagnesium bromide in the presence of a catalytic amount of titanium tetraisopropoxide leads to formation of the corresponding 1-aminoalkyl-1-cyclopropanols, e.g. II, in high yields. Hydrogenation of the latter over palladium catalyst ensures selective removal of one or two protecting benzyl groups from the nitrogen atom. The experimental process involved the reaction of 1-[(Dibenzylamino)methyl]cyclopropanol(cas: 428855-17-8).Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol

The Article related to aminoalkyl cyclopropanol asym synthesis benzyl amino acid ester cyclopropanation, aminoalkylcyclopropanol asym synthesis benzyl amino acid ester cyclopropanation, deprotection dibenzyl aminoalkyl cyclopropanol hydrogenation and other aspects.Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol

Referemce:
Alcohol – Wikipedia,
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On September 16, 2010, Ahmad, Saleem published a patent.Synthetic Route of 386704-04-7 The title of the patent was Preparation of aza-pyridone derivatives as antagonists of melanin concentrating hormone receptor-1 (MCHR1). And the patent contained the following:

Title compounds I [A1 and A2 independently = C or N; E = C or N; Q1, Q2 and Q3 independently = C or N provided that only one of them is N; D1 = bond, CC, 1,2-cyclopropyl, etc; R1, R2 and R3 independently = H, halogen, (un)substituted alkyl, etc; G = O, S or NR15; where R15 = H or (un)substituted alkyl; D2 = (un)substituted alkyl, cycloalkyl, cycloalkoxy, etc; Z1 and Z2 independently = H, (un)substituted alkyl, cycloalkyl, etc; R5, R6 and R7 independently = H, halogen, (un)substituted alkyl, etc], and their pharmaceutically acceptable salts or prodrugs, are prepared and disclosed. Thus, e.g., II was prepared by coupling reaction of (E)-4-chlorostyrylboronic acid with 6-chloro-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrimidin-4(3H)-one (preparation given). Compounds of the invention were evaluated for their antagonistic activity of peptide agonist binding to human melanin concentrating hormone receptor-1 (MCHR1), e.g., II exhibited Ki value of 23 nM. The invention compounds are useful for the treatment of MCHR1 mediated diseases, such as obesity, diabetes, inflammatory bowel disease, depression, and anxiety. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Synthetic Route of 386704-04-7

The Article related to aza pyridone preparation melanin concentrating hormone receptor antagonist, obesity diabetes depression anxiety mchr1 antagonist pyrimidinone preparation, inflammatory bowel disease mchr1 antagonist pyridazinone preparation and other aspects.Synthetic Route of 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts