Zubenko, A. A. et al. published their research in Russian Journal of General Chemistry in 2020 | CAS: 65-22-5

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Structural Modification of Pyridoxal. Synthesis and Evaluation of Anti-Infective Activity of New 4-Chloro- and 4-Alkyl(dialkyl)aminomethyl-2-hetaryl(hetaroyl)furo[2,3-c]pyridines was written by Zubenko, A. A.;Divaeva, L. N.;Morkovnik, A. S.;Fetisov, L. N.;Sochnev, V. S.;Kononenko, K. N.;Bodryakov, A. N.;Klimenko, A. I.. And the article was included in Russian Journal of General Chemistry in 2020.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

4-Hydroxymethyl-2-hetaryl(hetaroyl)furo[2,3-c]pyridines I [R = OH; R1 = PhCO, 4-BrC6H4CO, 2,3-dihydro-1,4-benzodioxine-6-carbonyl, 6-oxo-[1,3]dioxolo[4,5-g]chromen-8-yl], the products of furan cyclization of pyridoxal with Me halides, easily reacted with thionyl chloride in DMF to form new series of 4-chloromethyl-2-heteroaryl[2,3-c]pyridines I [R = Cl]. Further action of primary or secondary amines on these chloromethyl derivatives led to the nucleophilic substitution of chlorine atoms with the formation of 4-aminomethyl-2-heteroaryl[2,3-c]pyridines I [R = NHCH(Me)2, NHCH2CH2OMe, 1-piperidyl, morpholino]. The study of anti-infective activity of the compounds I showed significant protistocidal and moderate antibacterial activity of some of representatives of these compounds This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Category: alcohols-buliding-blocks).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts