Chiral Counteranion-Directed Catalytic Asymmetric Methylene Migration Reaction of Ene-Aldimines was written by Momiyama, Norie;Jongwohan, Chanantida;Ohtsuka, Naoya;Chaibuth, Pawittra;Fujinami, Takeshi;Adachi, Kiyohiro;Suzuki, Toshiyasu. And the article was included in Journal of Organic Chemistry in 2022.Recommanded Product: (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol The following contents are mentioned in the article:
A catalytic asym. methylene migration reaction of ene-aldimines directed by chiral counteranions was developed, with the optimal catalyst identified as phenanthryl-substituted (R)-BINOL phosphate. Control experiments and d. functional theory computations reveal the importance of the 2-hydroxy group of the ene-aldimine and attractive (e.g., OH···O, CH···O, CH···π, and π#183;··π) interactions for high enantioselectivity (up to 74% ee). The results contribute to the design of asym. catalysis for the rearrangement of highly reactive iminium intermediates. This study involved multiple reactions and reactants, such as (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1Recommanded Product: (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol).
(R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol
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