Ultrathin films to investigate the interaction of nitrofurantoin with phospholipids was written by Machado, Andre Campos;Caseli, Luciano. And the article was included in Thin Solid Films in 2021.Electric Literature of C37H74NO8P The following contents are mentioned in the article:
The mol. properties of the antibiotic nitrofurantoin at liquid interfaces were correlated with effects observed in cellular membrane models, represented by 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine Langmuir monolayers. Nitrofurantoin adsorbs at the films, keeps their compressibility, and stabilizes them, as characterized by tensiometry. Brewster Angle Microscopy and IR spectroscopy showed that nitrofurantoin induces the formation of aggregates and affects the lipid hydrophilic and hydrophobic chem. environments. Consequently, nitrofurantoin disturbs the cell membrane models, affecting some of their physicochem. properties, including thermodn., rheol., morphol., and structural. These results can help understand at the mol. level interactions between the drug and lipidic biol. surfaces. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Electric Literature of C37H74NO8P).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C37H74NO8P
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts