Tautomeric design of ortho-hydroxyheterocyclic Schiff bases was written by Kwocz, Agnieszka;Kochel, Andrzej;Chudoba, Dorota;Filarowski, Aleksander. And the article was included in Journal of Molecular Structure in 2015.Reference of 65-22-5 The following contents are mentioned in the article:
The article reports on the synthesis and crystallog. and theor. studies on various heterocyclic derivatives of ortho-hydroxy Schiff bases. The prevailing of one of the two (enolimine – OH and ketoamine – NH) tautomeric forms has been stated in studied compounds depending on the substitutes in heterocyclic formation, the nitrogen and carbon atoms of the imine group. A specific situation has been shown in (1E)-1-(5-chloro-2-hydroxy-3-nitrophenyl)ethanone oxime compound The potentials on the proton transfer of the hydrogen bridges in these compounds have been found out. Grounded on the obtained potential curves the influence of the protonation on nitrogen in the pyridoxal derivative of the studied ortho-hydroxy Schiff bases has been analyzed. The most efficient method of the impact (by means of various substitutes) on the intramol. tautomeric equilibrium in ortho-hydroxy Schiff bases has been presented. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Reference of 65-22-5).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 65-22-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts