Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking was written by Ivankin, Dmitry I.;Dyrkheeva, Nadezhda S.;Zakharenko, Alexandra L.;Ilina, Ekaterina S.;Zarkov, Timofey O.;Reynisson, Johannes;Luzina, Olga A.;Volcho, Konstantin P.;Salakhutdinov, Nariman F.;Lavrik, Olga I.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2022.Formula: C10H22O The following contents are mentioned in the article:
In this paper, novel thiazolidin-4-one derivatives I [R = R1OC6H4, R2; R1 or R2 = 3,7-dimethyloctyl, 3,7-dimethyloct-6-en-1-yl, Ph, etc.] with a benzyl and monoterpene substituents were synthesized. Compounds with a monoterpene fragment attached via a phenyloxy linker were active against TDP1 with IC50 values in the 1-3μM range, while direct attachment of monoterpene moiety to the thiazolidin-4-one fragment had no activity. Mol. modeling predicted two plausible binding modes of the active compounds both effectively blocking access to the catalytic site of TDP. At non-toxic concentrations the active ligands potentiated the efficacy of the TOP1 poison topotecan in human cervical cancer HeLa cells, but not in non-cancerous HEK293A cells. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Formula: C10H22O).
3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C10H22O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts