A rapid and naked-eye visible rhodamine 6G-based chemosensor for sensitive detection of copper(II) ions in aqueous solution was written by Huang, Q.;Chen, Y. T.;Ren, Y. W.;Wang, Z. Y.;Zhu, Y. X.;Zhang, Y.. And the article was included in Analytical Methods in 2018.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:
A new rhodamine 6G derivative (R6GHP) has been synthesized for quick recognition of copper(II) ions (Cu2+) in aqueous solutions The structure of R6GHP has been characterized by NMR and electrospray ionization mass spectrometry. Upon binding of Cu2+, the fluorescence intensity remarkably increases with about 36-fold enhancement. In addition, the color change from colorless to pink is visible to the naked eye. In optimal conditions, the fluorescence intensity and absorbance of R6GHP show good linearity with concentration of Cu2+ in the ranges of 1.0 × 10-6 to 1.0 × 10-5 mol L-1 and 1.0 × 10-6 to 1.2 × 10-5 mol L-1, resp., with detection limits of 3.9 × 10-7 mol L-1 and 1.0 × 10-6 mol L-1. Besides, it has been successfully applied to detect Cu2+ in two water samples. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride
Referemce:
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Alcohols – Chemistry LibreTexts