Chiral lithium salts of phosphoric acids as lewis acid-base conjugate catalysts for the enantioselective cyanosilylation of ketones was written by Hatano, Manabu;Ikeno, Takumi;Matsumura, Tokihiko;Torii, Shinobu;Ishihara, Kazuaki. And the article was included in Advanced Synthesis & Catalysis in 2008.Category: alcohols-buliding-blocks The following contents are mentioned in the article:
The catalytic enantioselective cyanosilylation of aromatic ketones was developed by using chiral lithium salts of (R)-BINOL- (BINOL = 2,2′-binaphthol) or (S)-BINAM-derived (BINAM = 2,2′-binaphthamine) phosphoric acid compounds In the presence of 10 mol% of chiral conjugate lithium salts, the corresponding tertiary cyanohydrins were obtained in high yields with moderate to high enantioselectivities. This is the 1st efficient example of asym. catalysis using lithium salts of synthetically useful chiral phosphoric acid compounds A possible catalytic mechanism and transition states are also discussed as a preliminary working hypothesis. This study involved multiple reactions and reactants, such as (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1Category: alcohols-buliding-blocks).
(R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts