Aryl ethers coupled pyridoxal as supramolecular gelator for selective sensing fluoride was written by Ghosh, Kumaresh;Pati, Chiranjit. And the article was included in Tetrahedron Letters in 2016.Synthetic Route of C8H10ClNO3 The following contents are mentioned in the article:
Aryl ethers coupled pyridoxal Schiff base 1 has been synthesized and its gelation properties have been examined The gelator 1 forms colorless gels from various solvents such as DMSO, DMF, DMSO/H2O and DMF/H2O. The gel matrix obtained from DMSO shows ribbon-like fibrous morphol. and has been utilized for efficient ‘naked eye’ detection of fluoride ion through a reversible gel-sol transition, which is associated with color change from almost colorless to yellow. In DMSO, the Schiff base 1 has also been observed to sense F– ion more efficiently over the basic ions AcO– and CN–. Though few examples of anion sensing in solution with pyridoxal-based Schiff bases are known, anion recognition utilizing pyridoxal-based gelators is unexplored in the literature. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Synthetic Route of C8H10ClNO3).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Synthetic Route of C8H10ClNO3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts