Weak Acid Permeation in Synthetic Lipid Vesicles and Across the Yeast Plasma Membrane was written by Gabba, Matteo;Frallicciardi, Jacopo;van ‘t Klooster, Joury;Henderson, Ryan;Syga, Lukasz;Mans, Robert;van Maris, Antonius J. A.;Poolman, Bert. And the article was included in Biophysical Journal in 2020.Formula: C37H74NO8P The following contents are mentioned in the article:
The authors present a fluorescence-based approach for determination of the permeability of small mols. across the membranes of lipid vesicles and living cells. With properly designed experiments, the method allows the authors to assess the membrane phys. properties both in vitro and in vivo. The permeability of weak acids increases in the order of benzoic > acetic > formic > lactic, both in synthetic lipid vesicles and the plasma membrane of Saccharomyces cerevisiae, but the permeability is much lower in yeast (one to two orders of magnitude). A relation between the mol. permeability and the saturation of the lipid acyl chain (i.e., lipid packing) in the synthetic lipid vesicles. were observed By analyzing wild-type yeast and a manifold knockout strain lacking all putative lactic acid transporters, the yeast plasma membrane is impermeable to lactic acid on timescales up to ∼2.5 h. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Formula: C37H74NO8P).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C37H74NO8P
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts