Diastereoselective Synthesis of Methanopyridoxazocinones was written by Detistov, Oleksandr S.;Panda, Siva S.;Steel, Peter J.;Asiri, Abdullah M.;Hall, C. Dennis;Katritzky, Alan R.. And the article was included in Synlett in 2014.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:
Two approaches to the synthesis of oxygen-bridged tetrahydropyridones have been developed. In the first approach, substituted pyrido[4,3-g][1,3]oxazocine derivatives were prepared by a diastereoselective one-pot reactions of substituted 7-azacoumarin derivatives with enolizable ketones and non-bulky primary amines. In the second one, 3-amido-7-azacoumarin derivatives were reacted with enolizable ketones in the presence of a base to form diastereomerically pure pyrido[4,3-g][1,3]oxazocine derivatives The synthesis of the target compounds was achieved by a reaction of the above-mentioned aza-coumarin derivs, 5-(hydroxymethyl)-8-methyl-2-oxo-2H-pyrano[2,3-c]pyridine-3-carboxamide, 5-(hydroxymethyl)-8-methyl-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-2H-pyrano[2,3-c]pyridin-2-one, 5-(hydroxymethyl)-8-methyl-3-(phenylsulfonyl)-2H-pyrano[2,3-c]pyridin-2-one with ketones and amines, amino acid esters. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride
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