Aliphatic Radical Relay Heck Reaction at Unactivated C(sp3)-H Sites of Alcohols was written by Chuentragool, Padon;Yadagiri, Dongari;Morita, Taiki;Sarkar, Sumon;Parasram, Marvin;Wang, Yang;Gevorgyan, Vladimir. And the article was included in Angewandte Chemie, International Edition in 2019.Recommanded Product: 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:
A radical relay Heck reaction which allows selective remote alkenylation of aliphatic alcs. at unactivated β-, γ-, and δ-C(sp3)-H sites is reported. The use of an easily installed/removed Si-based auxiliary enables selective I-atom/radical translocation events at remote C-H sites followed by the Heck reaction. Notably, the reaction proceeds smoothly under mild visible-light-mediated conditions at room temperature, producing highly modifiable alkenol products such as HOCRR1R2 [R = Me, n-Pr, i-Bu, etc.; R1 = H, Me; R2 = CH2C(Me)2CH=CHCN, CH2CHMeCH=CH(4-ClC6H4), CH2CHEtCH=CHCN, etc.] from readily available alcs. feedstocks. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Recommanded Product: 3,7-Dimethyloctan-1-ol).
3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 3,7-Dimethyloctan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts