Optimization of an ultrasound-assisted extraction method for the determination of parabens and bisphenol homologues in human saliva by liquid chromatography-tandem mass spectrometry was written by Moscoso-Ruiz, Inmaculada;Galvez-Ontiveros, Yolanda;Cantarero-Malagon, Samuel;Rivas, Ana;Zafra, Alberto. And the article was included in Microchemical Journal in 2022.Formula: C13H12O2 The following contents are mentioned in the article:
Parabens and bisphenols are endocrine disrupting chems. (EDCs) widely used in our daily lives. The main route of human exposure to these compounds is through the diet. This makes human saliva an important matrix for identification of these contaminants and evaluation of human exposure. In this work a multiresidue method to det the presence of methyl-, ethyl-, propyl-, isopropyl-, butyl- and isobutylparaben; and bisphenol A, B, C, E, F, M, P, S, Z, AP, AF and FL in human saliva samples has been developed. Sample treatment involves an initial step of protein pprotein in acidic medium and a second step of analyte extraction Extraction parameters were optimized using univariant and multivariant strategies. Microwave assisted extraction (MAE) and ultrasound assisted extraction (UAE) were compared and UAE was chosen the optimal extraction technique. The compounds were analyzed by ultra-high performance liquid chromatog. coupled to tandem mass spectrometry (UHPLC-MS/MS). The calibration in matrix was applied and the limits of detection and quantification were from 0.1 to 0.4 ng g-1 and from 0.3 to 1.0 ng g-1, respectivley. Accuracy was evaluated in terms of recovery (85.6 to 113.5%) with a relative standard deviation < 15% in all cases. The anal. method was successfully applied to quantify the target EDCs in ten human saliva samples, with some parabens being the most frequently detected compounds This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Formula: C13H12O2).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C13H12O2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts