Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation was written by Chelcea, Ioana;Oern, Stefan;Hamers, Timo;Koekkoek, Jacco;Legradi, Jessica;Vogs, Carolina;Andersson, Patrik L.. And the article was included in Environmental Science & Technology in 2022.Quality Control of 4,4′-Methylenediphenol The following contents are mentioned in the article:
Bisphenol A (BPA) is an industrial chem., which has raised human health and environmental concerns due to its endocrine-disrupting properties. BPA analogs are less well-studied despite their wide use in consumer products. These analogs have been detected in water and aquatic organisms around the world, with some analogs showing toxic effects in various species including fish. Here, we present novel organ-specific time-course distribution data of bisphenol Z (BPZ) in female zebrafish (Danio rerio), including concentrations in the ovaries, liver, and brain, a rarely sampled organ with high toxicol. relevance. Furthermore, fish-specific in vitro biotransformation rates were determined for 11 selected bisphenols. A physiol. based toxicokinetic (PBTK) model was adapted for four of these bisphenols, which was able to predict levels in the gonads, liver, and brain as well as the whole body within a 2-5-fold error with respect to exptl. data, covering several important target organs of toxicity. In particular, predicted liver concentrations improved compared to currently available PBTK models. Predicted data indicate that studied bisphenols mainly distribute to the carcass and gonads and less to the brain. Our model provides a tool to increase our understanding on the distribution and kinetics of a group of emerging pollutants. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Quality Control of 4,4′-Methylenediphenol).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of 4,4′-Methylenediphenol
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