Chakraborty, Moumita et al. published their research in Polyhedron in 2022 | CAS: 65-22-5

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 65-22-5

Cu(II) complexes of a bio-compatible aminoguanidine Schiff base: Histidine sensing and DNA-binding studies was written by Chakraborty, Moumita;Mohanty, Monalisa;Dinda, Rupam;Sengupta, Swaraj;Kumar Chattopadhyay, Shyamal. And the article was included in Polyhedron in 2022.Application of 65-22-5 The following contents are mentioned in the article:

Two Cu(II) complexes of pyridoxal-aminoguanidine Schiff base ligand with formula [Cu(HL)Cl]2(OAc)2·4H2O (1) and [Cu(HL)Cl(NCS)].H2O (2) are reported. The ligand and the complexes were characterized by their elemental analyses, ESI-MS, Uv-Vis, IR spectroscopy and cyclic voltammetric measurements. Single crystal structures of complex 1 and 2 were solved by X-ray diffraction. In both the Cu(II) complexes Cu(II) ions are in a square pyramidal geometry having geometry index (τ) value of 0.11 for complex 1 and 0.15 for complex 2. Both the complexes bind to calf-thymus DNA with binding constant comparable to ethidium bromide. CD studies revealed an intercalative mode of binding for both the complexes. In addition, the complexes also show promising cleavage of pUC19 supercoiled plasmid DNA with 1 showing the highest cleavage activity of ∼ 99%. In addition, both the complexes selectively recognize L-histidine amino acid. The low detection limit values (0.085μM and 0.19μM for complexes 1 and 2, resp.) ascertain the making of an efficient L-histidine biosensor. The absorption, emission and mass spectral results establish the formation of Cu(His)2 complex, with liberation of the fluorescent free ligand as the mechanism of sensing. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts