Surface interactions determined by stereostructure on the example of 7-hydroxycholesterol epimers – The Langmuir monolayer study was written by Chachaj-Brekiesz, Anna;Wnetrzak, Anita;Lipiec, Ewelina;Dynarowicz-Latka, Patrycja. And the article was included in Biochimica et Biophysica Acta, Biomembranes in 2019.Synthetic Route of C37H74NO8P The following contents are mentioned in the article:
Stereoselective interactions are pivotal for mol. recognition between biomols. and lipid surfaces. The aim of this study was to determine factors differencing mol. interactions between 7-hydroxycholesterol epimers (oxysterols, which excessively appear in pathol. processes in human body) and natural membrane phospholipids. Two-component systems of different mutual proportions of 7-hydroxycholesterol (7α-hydroxycholesterol or 7-β-hydroxycholesterol, in short 7α-OH or 7β-OH) and membrane lipids (POPC, DPPC, DPPE, DPPS, SM) were systematically analyzed in artificial membranes modeled as Langmuir monolayers. Classical surface pressure measurements were complemented with direct visualization of films texture both in situ (with Brewster angle microscopy, BAM) and after their transfer onto solid supports (with Atomic Force Microscopy, AFM). Our results clearly show striking differences in surface properties of the studied binary mixtures, emphasizing distinct effects of both 7-hydroxycholesterol epimers on the organization of lipid layers. Systematic study allowed to conclude that the structure of polar head group and interfacial region of the mol. play important role in oxysterol-phospholipid interactions, while the hydrophobic region is significantly less important in this respect. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Synthetic Route of C37H74NO8P).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C37H74NO8P
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Alcohols – Chemistry LibreTexts