Polygonum cuspidatum glycoside mitigated LPS-induced human endometrial stromal cell inflammation by regulating NF-κB/Nrf2 signaling pathway-related proteins was written by Wang, Wenjuan;Xiong, Zhengfang;Zeng, Xianghui. And the article was included in Tropical Journal of Pharmaceutical Research in 2022.Reference of 27208-80-6 The following contents are mentioned in the article:
To study the influence of polydatin on LPS-provoked human endometrial stromal cell inflammation, and its mechanism of action. Fifty ICR female mice were selected and assigned to control and three-dose polydatin groups. Before establishment of the model, mice in low-dose group, middle-dose group and high-dose group were given polydatin at doses of 5, 10 and 20 mg/kg, resp., by oral gavage for 5 days. Protein expression levels of interleukin 1β (IL-1 β), tumor necrosis factor- α (TNF-α) level, nuclear factor E2-related factor 2 (NRF-2) and nuclear transcription factor kappa-B (NF-2 κB) were determined with Western blot assay. Model group mice protein levels of NF- κB and nrf-2 were significantly reduced, relative to the corresponding control values (p < 0.05). The NF-κB and NRF-2 proteins in model group were markedly up-regulated, relative to control group, but they were and dose-dependently lower in the 3 polydatin groups than in control (p < 0.05). Polydatin reduces LPS-induced inflammatory response in mouse endometrial stromal cells, and promotes the repair of endometrium and regeneration of glands via a mechanism related to regulation of NF-κ B/Nrf2 signaling pathway-related proteins. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Reference of 27208-80-6).
(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 27208-80-6
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