Upadhyay, Yachana et al. published their research in Dalton Transactions in 2018 | CAS: 65-22-5

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 65-22-5

Three-in-one type fluorescent sensor based on a pyrene pyridoxal cascade for the selective detection of Zn(II), hydrogen phosphate and cysteine was written by Upadhyay, Yachana;Anand, Thangaraj;Babu, Lavanya Thilak;Paira, Priyankar;Crisponi, Guido;S K, Ashok Kumar;Kumar, Rajender;Sahoo, Suban K.. And the article was included in Dalton Transactions in 2018.Product Details of 65-22-5 The following contents are mentioned in the article:

A novel fluorescent receptor L was synthesized by Schiff base condensation of 1-pyrenemethylamine with the vitamin B6 cofactor pyridoxal. The receptor L is highly selective and sensitive towards Zn2+ ions among other tested metal ions. Upon interaction with Zn2+, the receptor L showed a distinct fluorescence enhancement at 485 nm due to the excimer formation leading to the fluorescent color change from blue to bluish-green. Subsequently, when the in situ generated ZnL2 complex interacted with various anions and amino acids, the addition of H2PO4– and cysteine reinstated the fluorescence of the receptor L due to the demetalation of Zn2+ from the ZnL2 complex. Accordingly, the receptor L was developed for the highly selective, specific and sensitive detection of three important bioactive analytes, i.e., Zn2+, H2PO4– and cysteine with a detection limit down to 2.3 × 10-6 M, 2.18 × 10-7 M and 1.59 × 10-7 M, resp. Addnl., the receptor L was applied to the detection of intracellular Zn2+ ions in live HeLa cells. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Product Details of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts