Eco-friendly and efficient synthesis, characterisation and antibacterial studies of unsymmetrical bidentate Schiff bases and their Zn(II) complexes was written by Srivastava, K. P.;Singh, Anuradha;Singh, Suresh Kumar. And the article was included in Oriental Journal of Chemistry in 2014.SDS of cas: 65-22-5 The following contents are mentioned in the article:
A rapid, efficient, clean and environmentally benign exclusive synthesis of Schiff bases as new ligands and their complexes with Zn(II) were developed using condensation of pyridoxal with amoxicillin, cephalexin, sulfamethoxazole and trimethoprim efficiently in an alc. suspension medium using alkali catalyst with excellent yields under microwaves irradiation This method provides several advantages such as environmental friendliness, simple work-up procedure, short reaction times, nonhazardous and excellent yield of products. The results are compared with conventional methods for their yield and reaction time. The Schiff base ligands and the complexes were characterized by micro-anal., thermo-gravimetric, magnetic and spectroscopic studies. All the Schiff bases were bidentate (NO donor) ligands. All complexes are six coordinate dihydrates and with 1:2 metal:ligand ratio. The complexes are colored and stable in air. All the complexes under study possess antibacterial activity. The antibacterial activity showed the following trend:. Zn(II)-complexes > Schiff base ligands > Parent drugs. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5SDS of cas: 65-22-5).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.SDS of cas: 65-22-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts