Siqueira, Josieli D. et al. published their research in Polyhedron in 2017 | CAS: 65-22-5

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 65-22-5

Synthesis, characterization and phosphatase inhibitory activity of dioxidovanadium(V) complexes with Schiff base ligands derived from pyridoxal and resorcinol was written by Siqueira, Josieli D.;Menegatti, Angela C. O.;Terenzi, Hernan;Pereira, Mateus B.;Roman, Daiane;Rosso, Eduardo F.;Piquini, Paulo C.;Iglesias, Bernardo A.;Back, Davi F.. And the article was included in Polyhedron in 2017.Reference of 65-22-5 The following contents are mentioned in the article:

In this manuscript, we report the synthesis of dioxidovanadium(V) complexes, their identification by spectroscopic and electrochem. methods, the structural characterization by X-ray diffraction and d. functional theory calculations, as well as their in vitro inhibitory activity of protein tyrosine phosphatases (PTPs). The structural anal. revealed the formation of dianionic complexes with [VO2]2+ species in compounds 1, [VO2(L1)]2[Et3NH]2 and 2, [VO2]2(L2)[(DBU-H)]2 (H2L1 = 2,4-(dihydroxyphenyl)ethylidene)benzohydrazide and H4L2 = bis[(3-hydroxy-5-(hydroxymethyl)-2methylpyridin-4-yl)methylene]oxalohydrazide. The mol. frontier orbitals of dioxidovanadium(V) complexes are characterized and compared. Furthermore, the enzymic experiments revealed that complex 1 inhibited at least two of the PTPs evaluated with potent activity (IC50 = 1.5 μM). This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Reference of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts