Sanchez-Martinez, Jose David published the artcileNeuroprotective potential of terpenoid-rich extracts from orange juice by-products obtained by pressurized liquid extraction, Name: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Food Chemistry: X (2022), 100242, database is CAplus and MEDLINE.
The agri-food industry plays a key role in many countries and economies, such as in Spain. Mong the different sectors, Spain is the largest producer of citrus juice in the European Union (EU) and one of the largest in the world. However, several environmental problems are associated to these activities, such as food waste generation. In 2013, the global citrus industry generated 24.3 million tons of waste, of which 1.3 million tons corresponded to Spain (mainly from the orange juice production). The recovery of bioactive compounds from plant material or agri – cultural waste through conventional techniques (such as maceration) involves several environmental constrains due to the important amount of organic solvents, large extraction times and high energy consumption requirements. In this sense, the use of advanced environmentally friendly extraction techniques such as pressurized liquid extraction (PLE), which uses high temperatures (above the b.p. and below the critical point) and pressures enough to maintain the solvent in the liquid state, presents some advantages, like the reduction of organic solvents volume and extraction times, and the improvement of the extraction yield of bioactive compounds through the increase of mass transfer rate between the solvent and the biomass. Hence, the aim of the present work is to optimize the PLE conditions to obtain terpenoids enriched extracts with neuroprotective properties from an orange juice byproduct and to characterize these extracts by using gas chromatog. coupled to high-resolution mass spectrometry (GC-q-TOF-MS) in order to increase the recovery of these compounds Moreover, the neuroprotective potential of the PLE orange extracts is explored and confirmed by a pool of in-vitro assays including anti-enzymic (AChE, BChE and LOX) and antioxidant (ABTS, ROS and RNS) tests. Finally, in-vitro cytotoxicity is evaluated by using different human cell culture models (HK-2, THP-1 and SH-SY5Y cells), as well as the potential anti-inflammatory capacity and neuroprotective activity against Aβ 1-42 and L-glutamic acid insults. Moreover, in-silico mol. docking is also applied to better understand the interaction between target mono- and sesquiterpenoids with acetylcholinesterase, butyrylcholinesterase and lipoxygenase active sites.
Food Chemistry: X published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Name: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts