Synthesis, x-ray crystal structures, spectroscopic and electrochemical studies of Zn(II), Cd(II), Ni(II) and Mn(II) complexes of N1,N4-bis(pyridoxylidene)triethylenetetramine was written by Mondal, Satyajit;Adak, Piyali;Das, Chandrima;Naskar, Sumita;Pakhira, Bholanath;Rheingold, Arnold L.;Sinn, Ekkehard;Eribal, Carla Sue;Chattopadhyay, Shyamal Kumar. And the article was included in Polyhedron in 2014.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:
Zn(II), Cd(II), Ni(II) and Mn(II) complexes of a new hexadentate ligand N1,N4-bis(pyridoxylidene)triethylenetetramine were synthesized. X-ray crystal structures show that in all the complexes the metal:ligand stoichiometry is 1:1 and the ligand coordinates in a di-deprotonated hexadentate manner through two phenolate oxygens, two imine nitrogens and two secondary amine N atoms. Fluorescence spectroscopy shows that the ligand centered emission undergoes 3-fold enhancement of intensity on complexation with Zn(II) ion, whereas it is quenched or remains unaffected in presence of various biol. relevant divalent metal ions. The Zn(II) specific fluorescence enhancement indicates that the ligand may be used as a fluorogenic sensor for Zn(II) in biol. systems, with a sensitivity of detection of 10-8 M. The electronic structures of the ligand as well as the complexes and their UV-visible absorption spectra are explained on the basis of DFT and TD-DFT calculations, resp. Covalence of the metal ligand bond follows the order Ni(II) >>> Mn(II) > Zn(II) ≈ Cd(II). This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts