A new pyridoxal based fluorescence chemo-sensor for detection of Zn(II) and its application in bio imaging was written by Mandal, Senjuti;Sikdar, Yeasin;Maiti, Dilip K.;Maiti, Guru Prasad;Mandal, Sushil Kumar;Biswas, Jayanta Kumar;Goswami, Sanchita. And the article was included in RSC Advances in 2015.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:
This paper describes the activity of a Schiff base ligand, derived from pyridoxal, as a promising fluorescence probe for biol. important Zn(II) ion sensing. A physiol. compatible pyridoxal based chemosensor PydDmen was synthesized and evaluated for its fluorescent response towards metal ions. Chemosensor PydDmen exhibits a selective turn-on type response in the presence of Zn2+ in ethanol-water mixture The addition of EDTA quenches the fluorescence of receptor PydDmen-Zn2+, making the chemosensor PydDmen reversible. The response is specific for Zn(II) ions, and remains almost unaffected by the presence of alkali and alk. earth metals but is suppressed to varying degrees by transition metal ions. The selectivity mechanism of PydDmen for Zn2+ is the combined effects of proton transfer between the prevailing tautomeric forms, C=N isomerization and CHEF. The DFT optimized structure of the complex is compatible with elemental anal., mass spectrometry, FT-IR, electronic and NMR spectra. The exptl. and theor. support in terms of NMR spectroscopy and DFT are provided to establish the existence of Zn2+ induced transformation of PydDmen to a 3-pyridone tautomeric form. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride
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