Toxicological profile of bisphenol F via comprehensive and extensive toxicity evaluations following dermal exposure was written by Lee, Sang-Sik;Ryu, Hyeon-Yeol;Ahn, Kyu-Sup;Lee, Somin;Lee, Jiho;Lee, Jae Won;Ko, Soo Min;Son, Woo-Chan. And the article was included in Journal of Toxicology and Environmental Health in 2022.Category: alcohols-buliding-blocks The following contents are mentioned in the article:
Bisphenol F (BPF) is classified as a harmful substance by the U. S. Environmental Protection Agency. Although previous studies focused on human exposure to BPF via direct consumption or inhalation, few investigators assessed potential toxicol. effects following skin contact. The aim of this study was to examine (1) the degree and pattern by which BPF is absorbed onto the skin in vivo, and (2) determination of toxicity and safety using the following tests: acute dermal; a 28-day repeat dermal; a skin irritation; an eye irritation; and a skin sensitization. As indicated by the amount of BPF remaining in the epidermis or dermis, data demonstrated that BPF was absorbed through the skin at a 26.5% rate. BPF penetrated the s.c. layer at a “fast rate” (Kp: 2.2E-02). Although no toxicol. changes or local irritation were observed following skin exposure, BPF induced potent sensitization. In summary, the findings of this study showed that BPF penetrated and was absorbed into the skin at a high rate which was associated with enhanced chem.-induced skin sensitization and this may have significant implications following exposure of skin to BPF. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Category: alcohols-buliding-blocks).
4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts