Klingstedt, Therese published the artcileSynthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates, Category: alcohols-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2011), 9(24), 8356-8370, database is CAplus and MEDLINE.
Mol. probes for selective identification of protein aggregates are important to advance the understanding of the mol. pathogenesis underlying protein aggregation diseases. Here the authors report the chem. design of a library of anionic luminescent conjugated oligothiophenes (LCOs), which can be utilized as ligands for detection of protein aggregates. Certain mol. requirements were shown to be necessary for detecting (i) early nonthioflavinophilic protein assemblies of Aβ1-42 and insulin preceding the formation of amyloid fibrils and (ii) for obtaining distinct spectral signatures of the two main pathol. hallmarks observed in human Alzheimer’s disease brain tissue (Aβ plaques and neurofibrillary tangles). The authors’ findings suggest that a superior anionic LCO-based ligand should have a backbone consisting of five to seven thiophene units and carboxyl groups extending the conjugated thiophene backbone. Such LCOs will be highly useful for studying the underlying mol. events of protein aggregation diseases and could also be utilized for the development of novel diagnostic tools for these diseases.
Organic & Biomolecular Chemistry published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Category: alcohols-buliding-blocks.
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